Every year, nearly 800,000 people worldwide take their own lives and far more attempt suicide. In 2015, suicide was responsible for 44,193 deaths in the U.S., which equates to about one suicide every 12 minutes. Suicide was ranked the 10th-leading cause of death in 2015 and has been among the top 12 leading causes of U.S. deaths since 1975. Unless one has experienced the loss of a loved one or friend by suicide, it\u2019s hard to imagine the pain and suffering it inflicts on survivors. Suicide Rates by State A number of studies provide data on which states have the highest suicide rates. In overall terms, states with lower happiness rankings have a higher prevalence of mental illness and lower rates of access to care for adults. In 2015, Wyoming, Alaska and Montana had the highest suicide rates per 100,000 population at 28.24, 26.83 and 25.25, respectively. Whereas in the latest happiness poll, Wyoming, Alaska and Montana were ranked 39, 41 and 23, respectively. Suicide Rates by Country The World Health Organization publishes suicide rates by region. In 2015, Europe had the highest suicide mortality rates of any region, while Sri Lanka had the highest rate of suicide in the world. Each of the following countries had the highest suicide rates in their respective region, listed by 100,000 population. \tSoutheast Asia \u2013 Sri Lanka: 35.3 \tEurope \u2013 Lithuania: 32.7 \tWestern Pacific \u2013 Republic of Korea: 32.0 \tAmericas \u2013 Guyana: 29.0 \tAfrica \u2013 Equatorial Guinea 22.6 \tEastern Mediterranean \u2013 Sudan: 10.2 Suicide Risk Factors Suicide impacts males and females of all ages, socioeconomic backgrounds and ethnicities. Major depressive disorder impacts more than 16.1 million American adults ages 18 and older, or about 6.7% of the U.S. population. Ninety percent of all people who die by suicide have a diagnosable psychiatric disorder at the time of death. More than 50% of all suicide deaths involve major depression. Genetic, biological, psychological, social and cultural factors also play a role, often in context with trauma or loss. Major risk factors include: \tDepression \tOther mental health disorders \tSubstance abuse \tSerious or chronic health condition (e.g. pain) \tA prior suicide attempt \tFamily history of a mental disorder, substance abuse or suicide \tFamily violence (e.g. physical or sexual abuse) \tStressful life events (e.g. death, divorce or job loss) \tProlonged stress factors (e.g. sexual harassment or bullying) \tGuns or other firearms in the home \tRecent release from prison \tExposure to suicidal behavior (e.g. family members, peers or celebrities) Suicide Warning Signs If you experience or notice any of the following warning signs in others, seek professional help. \tTalking about wanting to die or kill oneself \tLooking for a method to take one\u2019s life (e.g. searching online or buying a gun) \tExpressing feelings of hopelessness or no reason to live \tTalking about feeling trapped or in unbearable pain \tStating one is a burden to others \tUsing alcohol or drugs increasingly \tActing anxious or agitated (e.g. behaving recklessly) \tSleeping too little or too much \tWithdrawing or isolating oneself \tShowing rage or talking about seeking revenge \tExhibiting extreme mood swings Suicide prevention strategies need to be multifactorial and tailored to the individual. If you or someone you know is exhibiting suicide warning signs, it is essential to seek intervention immediately. In many instances, effective depression treatment helps alleviate symptoms, giving people newfound hope and reducing the risk of suicide.